1-(5-Bromo-2-fluorophenyl)ethanol → 1-(5-Bromo-2-fluorophenyl)ethanone
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([CH:8]([OH:10])[CH3:9])[CH:7]=1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1参加物
4
実験手順
To a solution of 1-(5-bromo-2-fluoro-phenyl)-ethanol 102 (105 g, 0.479 mol.) in dioxane (2 L) was added manganese dioxide (203 g, 2.35 mol.). The reaction mixture was heated under reflux for 5 hours. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through Celite (i.e., diatomaceous earth) and the solid was washed with ether (1 L). The combined filtrate was evaporated under reduced pressure to afford the 1-(5-bromo-2-fluoro-phenyl)-ethanone 103 (95.7 g, 0.441 mol.) which was used in the next step without further purification.
後処理
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 5 hours
- filtrationThe reaction mixture was filtered through Celite (i.e., diatomaceous earth)
- washthe solid was washed with ether (1 L)
- customThe combined filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-bdd85ab70f194254afbddf83ff28da8c
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528132B2
反応ノート
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