化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 4-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | tert-butyl(2R)-2-[(dimethylamino)carbonyl]-4-fluoropyrrolidine-1-carboxylate | HCID 69064202 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate | HCID 69061831 | — |
反応手順
10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.09 g of the compound obtained in step 6-2, after which the reaction mixture was stirred for 2 hours at room temperature. The reaction mixture was then concentrated under reduced pressure, which gave 3.42 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07528124B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-cd9a3c58831a439fa2eb5c0b3085fd58 |
| 出典メモ | uspto-grants-2009_05 |