Dimethylmaleic anhydride → methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate

HRID 4902

反応式

HRID 4902 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([S:12]([NH2:15])(=[O:14])=[O:13])[CH:3]=1.[CH3:16][C:17]1[C:18]([O:20][C:21](=O)[C:22]=1[CH3:23])=[O:19]>C(O)(=O)C>[NH2:15][S:12]([C:4]1[CH:3]=[C:2]([N:1]2[C:18](=[O:19])[C:17]([CH3:16])=[C:22]([CH3:23])[C:21]2=[O:20])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])(=[O:13])=[O:14]

参加物

4

反応物 2

HCID 13010Dimethylmaleic anhydrideHCID 10977277Methyl 4-amino-2-sulfamoylbenzoate

生成物 1

HCID 14837212methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate収率 43%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

In 3 ml of acetic acid, 1 mmol of methyl 4-amino-2-(aminosulfonyl)benzoate and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 80° C. for 40 hours. Acetic acid was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water to the oily residue. After the mixture thus formed was stirred for 2 hours, the resulting precipitate was collected by filtration and then dried in air. Yield: 43%. Its physicochemical properties are shown in Table 8.

後処理

  1. distillationAcetic acid was then distilled off from the reaction mixture
  2. additionfollowed by the addition of 20 ml of ice water to the oily residue
  3. customAfter the mixture thus formed
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried in air

出典と根拠

ORDレコード
ord-b9ac6e1cabe64925a2abe6ef104073ff
出典データセット
uspto-grants-1993_09
特許番号
US05242894

関連ノート

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