Ammonia → 3-(Morpholin-4-yl)propane-1-sulfonamide
反応式
[NH3:1].C(=O)=O.CC(C)=O.[N:9]1([CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>ClCCl>[N:9]1([CH2:15][CH2:16][CH2:17][S:18]([NH2:1])(=[O:20])=[O:19])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1参加物
5
実験手順
Dichloromethane (40 ml) was saturated with ammonia gas with cooling (dry ice/acetone), and then 3-morpholin-4-yl-propane-1-sulphonyl chloride (279 mg, 1.23 mmoles) was added. The mixture was stirred at room temperature for 24 hours. The mixture was filtered, the filtrate evaporated and the residue was dried at 40° C. in vacuo to afford compound 58 (210 mg) as a gum. LC/MS System A; Rt=0.28 mins, m/z (ES+)=209 (M+H for C7H16N2O3S).
後処理
- filtrationThe mixture was filtered
- customthe filtrate evaporated
- customthe residue was dried at 40° C. in vacuo
出典と根拠
- ORDレコード
- ord-dc6daf353b524388bfa92a83a2bcf80f
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528157B2
反応ノート
読み込み中…