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[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol → 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol | HCID 22042151 | — |
| 触媒 | Manganese oxide | HCID 160959 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde | HCID 22042114 | 86.1% |
反応手順
Manganese oxide (3.75 g, 43.1 mmol) was added portionwise to [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol (660 mg, 2.53 mmol) dissolved in dichloromethane (68 mL) under nitrogen at room temperature. The precipitate was filtered through celite, washing with hot dichloromethane. The filtrate was concentrated to give 563 mg (83%) of 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde as a waxy brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706709B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-d60fafba983a46b6afe1da41a9ce5d74 |
| 出典メモ | uspto-grants-2004_03 |