化工社化工社 化学情報印刷レポート · 研究参考用
1-(p-Tolyl)piperazine → [(2S,4S)-1-Benzyl-4-(2,4-difluoro-benzylamino)-pyrrolidin-2-yl]-(4-p-tolyl-piperazin-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(p-Tolyl)piperazine | HCID 83113 | — |
| 反応物 | 1-Benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid | HCID 67547470 | — |
| 生成物 | [(2S,4S)-1-Benzyl-4-(2,4-difluoro-benzylamino)-pyrrolidin-2-yl]-(4-p-tolyl-piperazin-1-yl)-methanone | HCID 67548059 | 2.6% |
反応手順
As described for Example 1f, 1-benzyl-4-[tert-butoxycarbonyl-(2,4-difluoro-benzyl)-amino]-pyrrolidine-2-carboxylic acid (60.0 mg, 0.134 mmol) was converted, using 1-p-tolyl-piperazine instead of 2-piperazin-1-yl-benzonitrile, to the title compound (1.8 mg, 2.6%) as light yellow oil. MS m/e=505.4 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07528136B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-fc184cf34c5a48b98b4a5c850e9cd027 |
| 出典メモ | uspto-grants-2009_05 |