戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 490635作成日：2026年10月26日

1-(m-Tolyl)piperazine → [(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanone

https://huagongshe.com/reaction/490635

反応式

関与物質

役割名称HCID仕込み量
反応物1-(m-Tolyl)piperazineHCID 83111—
反応物1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acidHCID 86625301—
生成物[(2s,4s)-1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-(4-m-tolyl-piperazin-1-yl)-methanoneHCID 874401428.5%

反応手順

As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using 1-m-tolyl-piperzine instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (7.5 mg, 8.5%) as light yellow oil. MS m/e=605.4 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07528136B2
出典データセットuspto-grants-2009_05
ORD IDord-d2d32b50641540d4be6fa03fbb04c6bd
出典メモuspto-grants-2009_05