化工社化工社 化学情報印刷レポート · 研究参考用
1-Benzoylpiperazine → (4-Benzoyl-piperazin-1-yl)-[(2S,4S)-1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzoylpiperazine | HCID 762654 | — |
| 反応物 | 1-Benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid | HCID 86625301 | — |
| 生成物 | (4-Benzoyl-piperazin-1-yl)-[(2S,4S)-1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidin-2-yl]-methanone | HCID 86625305 | 12.1% |
反応手順
As described for Example 56d, 1-benzyl-4-(3,5-bis-trifluoromethyl-benzylamino)-pyrrolidine-2-carboxylic acid (65 mg, 0.146 mmol) was converted, using phenyl-piperazin-yl-methanone instead of 1-(3-trifluoromethyl-phenyl)-piperazine, to the title compound (10.9 mg, 12.1%) as light yellow oil. MS m/e=619.4 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07528136B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-025d1e0e3d9f4b28adbf35b076db4cb1 |
| 出典メモ | uspto-grants-2009_05 |