Piperidine → 3-[5-(2-Morpholin-4-yl-ethoxy)-1H-indol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

HRID 49089

反応式

HRID 49089 の反応式
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:11]([NH2:14])(=[O:13])=[O:12])[CH:8]=2)[NH:3]1.[N:15]1([CH2:21][CH2:22][O:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[NH:29][C:28]([CH:33]=O)=[CH:27]3)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.N1CCCCC1>C(O)C>[N:15]1([CH2:21][CH2:22][O:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[NH:29][C:28]([CH:33]=[C:10]2[C:9]4[C:4](=[CH:5][CH:6]=[C:7]([S:11]([NH2:14])(=[O:12])=[O:13])[CH:8]=4)[NH:3][C:2]2=[O:1])=[CH:27]3)[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

参加物

5

反応物 3

HCID 8082PiperidineHCID 101982322-Oxoindoline-5-sulfonamideHCID 220421095-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde

生成物 1

HCID 693434073-[5-(2-Morpholin-4-yl-ethoxy)-1H-indol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide収率 73.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide (27 mg, 0.12 mmol), 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde (30 mg, 0.11 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 90° C. for 2 hours. The reaction was cooled at 0° C. for overnight. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give 38 mg (62%) of the title compound as an orange solid.

後処理

  1. temperatureThe reaction was cooled at 0° C. for overnight
  2. filtrationThe precipitate was collected by vacuum filtration
  3. washwashed with cold ethanol
  4. customdried

出典と根拠

ORDレコード
ord-e3f6aac9d2af4f57ace14d07b31f7923
出典データセット
uspto-grants-2004_03
特許番号
US06706709B2

関連ノート

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