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HRID 490895作成日：2026年10月26日

phenylalaninol, (R)- → 1-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

https://huagongshe.com/reaction/490895

反応式

関与物質

役割名称HCID仕込み量
反応物phenylalaninol, (R)-HCID 853475—
反応物1-Ethyl-N-[(1R)-2-hydroxy-1-phenylethyl]-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 11281295—
反応物1-Ethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acidHCID 53487829—
生成物1-Ethyl-N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-4-(tetrahydro-2H-pyran 4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideHCID 57675224—

反応手順

Intermediate 45 was prepared from Intermediate 17 and (2R)-2-amino-3-phenyl-1-propanol (commercially available from Aldrich) using an analagous method to that for Intermediate 42. LCMS showed MH+=424; TRET=2.59 min.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07528148B2
出典データセットuspto-grants-2009_05
ORD IDord-0b1b452c082740d29ac3d49a51d0c15e
出典メモuspto-grants-2009_05