Hydrochloric Acid → 1-Ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide hydrochloride

HRID 490907ノート

反応式

HRID 490907 の反応式
[CH2:1]([N:3]1[C:7]2=[N:8][C:9]([CH3:30])=[C:10]([C:19]([NH:21][NH:22]C(OC(C)(C)C)=O)=[O:20])[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].[ClH:31]>O1CCOCC1>[ClH:31].[CH2:1]([N:3]1[C:7]2=[N:8][C:9]([CH3:30])=[C:10]([C:19]([NH:21][NH2:22])=[O:20])[C:11]([NH:12][CH:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 576752221,1-Dimethylethyl 2-{[1-ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]carbonyl}hydrazinecarboxylate

生成物 1

HCID 675290551-Ethyl-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carbohydrazide hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
20 °C

実験手順

Intermediate 62 (0.19 g, 0.46 mmol) was dissolved in 4M hydrogen chloride in dioxane (5 ml) and the reaction mixture stirred overnight at 20° C. Concentration in vacuo afforded Intermediate 63 as a white solid (0.161 g). LCMS showed MH+=319; TRET=1.72 min.

後処理

  1. concentrationConcentration in vacuo

出典と根拠

ORDレコード
ord-ddaeac8eb3364d40b07caaef856891fb
出典データセット
uspto-grants-2009_05
特許番号
US07528148B2

反応ノート

読み込み中…