1,2-Dichloroethane → HCID 67374131、化合物

HRID 490933

反応式

HRID 490933 の反応式
[CH2:1]([O:8][C:9]([NH:11][CH:12]([P:16]([OH:18])[OH:17])[CH:13]([CH3:15])[CH3:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19](Cl)[CH2:20]Cl>C(O)C.C(Cl)Cl>[CH2:19]([O:18][P:16]([CH:12]([NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH:13]([CH3:15])[CH3:14])[OH:17])[CH3:20]

参加物

5

反応物 2

HCID 111,2-DichloroethaneHCID 213258521-Carbobenzyloxyamino-2-methylpropanephosphonous acid

生成物 1

HCID 67374131HCID 67374131、化合物収率 96.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid (5.8 g, 21.4 mmol) in 15 mL ethanol and 200 mL CH2Cl2 was added EDC (5.0 g, 26 mmol). The resulting reaction mixture was stirred at ambient temperature for 30 minutes. The mixture was concentrated in vacuo, and the residue was taken up into 200 mL ethyl acetate, washed with water and brine. The solvent was evaporated in vacuo to afford 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid ethyl ester (6.2 g, 20.7 mmol, 96.8%) as white solid which was used without further purification.

後処理

  1. customThe resulting reaction mixture
  2. concentrationThe mixture was concentrated in vacuo
  3. washwashed with water and brine
  4. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-0a69862bc7064ed7be2c6c6674f27955
出典データセット
uspto-grants-2009_05
特許番号
US07528173B2

関連ノート

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