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Hydrochloric Acid → 4-bromo-3-(trifluoromethyl)aniline HCl salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Bromo-3-(trifluoromethyl)aniline | HCID 67852 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-bromo-3-(trifluoromethyl)aniline HCl salt | HCID 66745707 | 98% |
反応手順
To a solution of 4-bromo-3-(trifluoromethyl)aniline (64 g, 267 mmol) in Et2O (500 mL) was added an HCl solution (1 M in Et2O; 300 mL) dropwise and the resulting mixture was stirred at room temp. for 16 h. The resulting pink-white precipitate was removed by filtration and washed with Et2O (50 mL) and to afford 4-bromo-3-(trifluoromethyl)aniline HCl salt (73 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07528255B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-6ce5a368866f4d38a33d544009dbcb7d |
| 出典メモ | uspto-grants-2009_05 |