反応式
C[O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>>[OH:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([F:13])([F:14])[F:15]参加物
3
反応条件
- 温度
- 180 °C
実験手順
10.0 g (45.4 mmol) 4-methoxy-3-trifluoromethyl-benzoic acid and 75 g pyridinium-hydrochloride were mixed well and then heated to 180° C. under a nitrogen atmosphere for 5 h. The reaction mixture was poured onto 1 L 10% citric acid solution and extracted with 50 mL EtOAc. The organic phase was washed with 1 L water and dried over Na2SO4. After the desiccant and solvent had been eliminated the product was further reacted without purification.
後処理
- extractionextracted with 50 mL EtOAc
- washThe organic phase was washed with 1 L water
- dry with materialdried over Na2SO4
- customwas further reacted without purification
出典と根拠
- ORDレコード
- ord-3592c36111624b0c9a30edf57426b151
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528129B2
関連ノート
読み込み中…