Tert-Butylamine → N-t-Butyl 3-bromobenzamide

HRID 491228ノート

反応式

HRID 491228 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:6]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 74377Benzoyl chloride, 3-bromo-

生成物 1

HCID 603211N-t-Butyl 3-bromobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 3-bromo-benzoyl chloride (0.83 g, 3.8 mmol) in DCM (10 mL) was chilled to zero degrees and treated with tert-butylamine (1.2 mL, 11.3 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (0.9 g, 94%).

後処理

  1. customReaction
  2. customto come to room temperature
  3. additionMixture was then poured onto water
  4. washwashed once
  5. washOrganic phase then washed with brine
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to amber oil (0.9 g, 94%)

出典と根拠

ORDレコード
ord-5d1e6cbf2a7b481bb2e3250b5c55136e
出典データセット
uspto-grants-2009_05
特許番号
US07528143B2

反応ノート

読み込み中…