Triethylamine → HCID 68857974、化合物

反応式

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5]N=1.[Cl:12][C:13]1[C:21]2[C:20]([NH:22][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=3)=[N:19][CH:18]=[N:17][C:16]=2[S:15][CH:14]=1.[CH3:32]CN(CC)CC>C(Cl)Cl>[Cl:12][C:13]1[C:21]2[C:20]([NH:22][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][C:7](=[O:8])[C:6]4[CH:5]=[CH:32][C:3]([O:2][CH3:1])=[CH:11][CH:10]=4)=[CH:27][CH:26]=3)=[N:19][CH:18]=[N:17][C:16]=2[S:15][CH:14]=1

参加物

実験手順

A solution of 6-methoxynicotinoyl chloride (343 mg, 2 mmol) in CH2Cl2 (5 mL) was added dropwise to a solution of 4-{2-[(5-chlorothieno[2,3-d]pyrimidin-4-yl)amino]ethyl}phenol (611 mg, 2 mmol) and Et3N (1.0g, 10 mmol) in CH2Cl2 (5 mL) and the solution was stirred at room temperature overnight. The reaction was diluted with CH2Cl2 (20 mL) and washed with H2O, 1M NaOH, and brine. The organics were dried (Na2SO4) and filtered through silica gel. The solvent was stripped yielding 200 mg of material which was purified via HPLC giving 48mg, 0.11 mmol, 5 percent yield.