3-Methoxytyramine → 4-[2-(5-Chlorothieno[2,3-d]pyrimidin-4-ylamino)ethyl]-2-methoxyphenol

HRID 491266

反応式

HRID 491266 の反応式
Cl[C:2]1[C:3]2[C:10]([Cl:11])=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([O:22][CH3:23])[CH:16]=1.C(N(CC)CC)C>CN(C=O)C.O>[Cl:11][C:10]1[C:3]2[C:2]([NH:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([O:22][CH3:23])[CH:16]=3)=[N:7][CH:6]=[N:5][C:4]=2[S:8][CH:9]=1

参加物

6

反応物 3

HCID 16693-MethoxytyramineHCID 8471TriethylamineHCID 157457684,5-Dichlorothieno[2,3-d]pyrimidine

生成物 1

HCID 688569804-[2-(5-Chlorothieno[2,3-d]pyrimidin-4-ylamino)ethyl]-2-methoxyphenol収率 76%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 4,5-dichlorothieno[2,3-d]pyrimidine (2.0 g, 9.8 mmol), 4-(2-aminoethyl)-2-methoxyphenol (1.8 g, 10.7 mmol) and triethylamine (1.2 g, 11.8 mmol) in DMF (15 mL) was stirred overnight. The solution was diluted with H2O and the product collected by filtration yielding an off white powder, 2.5 g, 7.4 mmol, 76 percent yield.

後処理

  1. filtrationthe product collected by filtration
  2. customyielding an off white powder, 2.5 g, 7.4 mmol, 76 percent yield

出典と根拠

ORDレコード
ord-2815d09f82de493285b790fdf2f57820
出典データセット
uspto-grants-2009_05
特許番号
US07531482B2

関連ノート

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