[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol → 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

HRID 491293

反応式

HRID 491293 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:9]2[CH3:15])=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH:13]=[O:14])[N:10]=[C:9]2[CH3:15])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 67303957[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

生成物 1

HCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol is dissolved in methylene chloride. Manganese (IV) oxide is added and the reaction mixture is stirred at room temperature for 3 days. The suspension is filtered through a dicalite speed plus pad and the desired compound (4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde is obtained.

後処理

  1. filtrationThe suspension is filtered through a dicalite speed plus pad

出典と根拠

ORDレコード
ord-8b897ca23539406ab8a06219ab41d833
出典データセット
uspto-grants-2009_05
特許番号
US07531529B2

関連ノート

読み込み中…