[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol → 1-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

HRID 491334

反応式

HRID 491334 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH2:13][OH:14])[N:10]=[C:9]2[CH3:15])=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([CH:13]=[O:14])[N:10]=[C:9]2[CH3:15])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 67303957[1-(4-fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol

生成物 1

HCID 859979931-(4-fluoro-phenyl)-2-methyl-1H-imidazole-4-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-yl]-methanol (7.16 g, 34.7 mmol) was dissolved in 2.3 L methylene chloride. Manganese (IV) oxide (26.8 g, 278 mmol) was added and the reaction mixture was stirred at room temperature for 3 days. The suspension was filtered through a dicalite speed plus pad and washed with 1 L methylene chloride. The solvents were evaporated and the desired compound was obtained as a white solid (5.87 g, 83%), MS: m/e=205.1 (M+H+).

後処理

  1. filtrationThe suspension was filtered through a dicalite speed plus pad
  2. washwashed with 1 L methylene chloride
  3. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-49d5a6ea48f948868751d4fd5e04bdfe
出典データセット
uspto-grants-2009_05
特許番号
US07531529B2

関連ノート

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