Sodium Iodide → [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Iodide	HCID 5238	—
反応物	Diisopropylethylamine	HCID 81531	—
反応物	1H-Pyrazol-3-amine, 5-methyl-	HCID 93146	—
反応物	4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine	HCID 13413724	—
溶媒	1-Butanol	HCID 263	—
生成物	[6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine	HCID 178419077	—

反応条件

温度	120 °C

反応手順

To a solution of above-prepared 4,6-dichloro-2-(4-methoxy-benzylsulfanyl)-pyrimidine (915 mg, 3.04 mmol) and 3-amino-5-methylpyrazole (310 mg, 3.19 mmol) in BuOH (20 mL) is added diisopropylethylamine (0.56 mL, 3.19 mmol) followed by sodium iodide (455 mg, 3.04 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gardient) to give [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07531536B2
出典データセット	uspto-grants-2009_05
ORD ID	ord-964fe14b52944a1fb0fa8aa64bf94a39
出典メモ	uspto-grants-2009_05