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HRID 491455作成日：2026年10月27日

4-Ethyl-2,3-dioxopiperazinecarbonyl chloride → 1-(1-{4-[(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-1-oxo4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-methanoyl)-4-ethyl-piperazine-2,3-dione

https://huagongshe.com/reaction/491455

反応式

関与物質

役割名称HCID仕込み量
反応物4-Ethyl-2,3-dioxopiperazinecarbonyl chlorideHCID 108813—
反応物(4aS,8aR)-4-(3,4-Diethoxyphenyl)-2-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-oneHCID 10175016—
生成物1-(1-{4-[(4aS,8aR)-4-(3,4-Dimethoxyphenyl)-1-oxo4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-methanoyl)-4-ethyl-piperazine-2,3-dioneHCID 9828642—

反応手順

Prepared from 4-ethyl-2,3-dioxo-piperazine-1-carbonyl chloride and starting compound A1 as described for compound 1. Crystallisation from ethyl acetate/diethyl ether. M.p. 226-228° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07531540B2
出典データセットuspto-grants-2009_05
ORD IDord-56da14b202404792b32d8c6cf0e2376e
出典メモuspto-grants-2009_05