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HRID 49146作成日：2026年10月25日
5-Decene → 5-(2-Ethoxy-ethyl)-5-[4-(4-[1,3,4]oxadiazol-2-yl-phenoxy)-phenoxy]-pyrimidine-2,4,6-trione
https://huagongshe.com/reaction/49146
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Decene | HCID 23916 | — |
| 反応物 | 4,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolane | HCID 197408 | — |
| 反応物 | 4-(4-[1,3,4]Oxadiazol-2-yl-phenoxy)-phenol | HCID 20636235 | — |
| 反応物 | 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 21931123 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5-(2-Ethoxy-ethyl)-5-[4-(4-[1,3,4]oxadiazol-2-yl-phenoxy)-phenoxy]-pyrimidine-2,4,6-trione | HCID 11442355 | 53% |
反応手順
A mixture of 4-(4-[1,3,4]oxadiazol-2-yl-phenoxy)-phenol (0.90 g, 2.5 mmol), 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (1.0 g, 3.6 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 2.4 g, 6.1 mmol) and 11.7 mL of acetonitrile was shaken at 23° C. for 24 hours. The mixture was diluted with 30 mL of 25% acetic acid in methanol, filtered, and the solids were washed twice with methanol-acetic acid. The filtrate was concentrated in vacuo and purified by radial chromatography (2:1 to 1:1 hexane-ethyl acetate), affording 600 mg of 5-(2-Ethoxy-ethyl)-5-[4-(4-[1,3,4]oxadiazol-2-yl-phenoxy)-phenoxy]-pyrimidine-2,4,6-trione as a colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06706723B2 |
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| 出典データセット | uspto-grants-2004_03 |
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| ORD ID | ord-21298f32c3a047b0abafc82119c4f1d0 |
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| 出典メモ | uspto-grants-2004_03 |
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