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Bromine → Diethyl 4-Bromo-2-methylbenzylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Phosphonic acid, P-((2-methylphenyl)methyl)-, diethyl ester | HCID 112945 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Trimethyl Phosphate | HCID 10541 | — |
| 生成物 | Diethyl 4-Bromo-2-methylbenzylphosphonate | HCID 19797190 | — |
反応手順
10 g (42 mmol) of diethyl 2-methylbenzylphosphonate were dissolved in 60 ml of trimethyl phosphate and the solution was introduced into a flask protected from light and moisture. 16 g (0.05 mol) of Br2 were added dropwise, while stirring. The mixture was stirred at 90° C. for 15 hours and, after cooling, was diluted with 100 ml of water and extracted three times with 100 ml of n-hexane each time. The organic phase wa dried, concentrated and distilled.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242908 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-d600937ba404454f851cb18c5c96b0b1 |
| 出典メモ | uspto-grants-1993_09 |