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Propionamide → N-(4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-benzyl)-propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propionamide | HCID 6578 | — |
| 反応物 | 5-Decene | HCID 23916 | — |
| 反応物 | 4,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolane | HCID 197408 | — |
| 反応物 | N-[4-(4-Hydroxy-phenoxy)-benzyl]-propionamide | HCID 20636237 | — |
| 反応物 | 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 21931123 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-benzyl)-propionamide | HCID 20636226 | — |
反応手順
Following the procedure outlined for the preparation of Example 1, N-[4-(4-hydroxy-phenoxy)-benzyl]-propionamide (0.13 g, 0.47 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.13 g, 0.48 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 0.31 g) and 1.55 mL of acetonitrile, benzyl)-propionamide (0.060 g) as a colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706723B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-4a89fc67434542439b5e46a12ded1604 |
| 出典メモ | uspto-grants-2004_03 |