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5-Decene → 4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Decene | HCID 23916 | — |
| 反応物 | 4,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolane | HCID 197408 | — |
| 反応物 | 4-(4-hydroxy-phenoxy)-N-methyl-benzamide | HCID 18184026 | — |
| 反応物 | 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 21931123 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide | HCID 20636128 | 15.6% |
反応手順
Following the procedure outlined for the preparation of Example 1 4-(4-hydroxy-phenoxy)-N-methyl-benzamide (0.14 g, 0.58 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.16 g, 0.58 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 0.40 g) and 2.0 mL of acetonitrile, affording 4-{4-[5-(2-ethoxy-ethyl)-2,4,6-trioxo-hexahydro-pyrimidin-5-yloxy]-phenoxy}-N-methyl-benzamide (0.040 g) as a colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706723B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-fc9f32ca787f4719a24f9d4f9ee20304 |
| 出典メモ | uspto-grants-2004_03 |