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5-Decene → HCID 20636172、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Decene | HCID 23916 | — |
| 反応物 | 4,4',5,5,5',5'-Hexafluoro-2,2,2',2'-tetrakis(trifluoromethyl)-4,4'-bi-1,3-dioxolane | HCID 197408 | — |
| 反応物 | 4-(4-Aminomethyl-phenoxy)-phenol | HCID 20636236 | — |
| 反応物 | 5-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione | HCID 21931123 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 20636172 | HCID 20636172 | 18.1% |
反応手順
Following the procedure outlined for the preparation of Example 1, 4-(4-aminomethyl-phenoxy)-phenol (0.70 g, 3.32 mmol) was reacted with 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.95 g, 2.4 mmol), 1,5,7-trazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (PTBD, Fluka, 2.22 9) and 11 mL of acetonitrile, affording 5-[4-(4-aminomethyl-phenoxy)-phenoxy]-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (0.180 g) as a colorless solid after purification by reverse phase HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706723B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-9773a3e6fb4449d6ab49be98cb635123 |
| 出典メモ | uspto-grants-2004_03 |