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Sulfuric Acid → Diethyl 2-carboxybenzylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Phosphonic acid, P-((2-methylphenyl)methyl)-, diethyl ester | HCID 112945 | — |
| 反応物 | Potassium Permanganate | HCID 516875 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Diethyl 2-carboxybenzylphosphonate | HCID 11369294 | — |
反応手順
4 g of diethyl 2-methylbenzylphosphonate were added to a solution of 12 g of KMnO4 and 4 g of Na2CO3 in 300 ml of water and the mixture was boiled under reflux for 24 hours. It was acidified with 15 ml of concentrated H2SO4 and extracted five times with 300 ml of ether each time. The organic phase was dried over MgSO4, the solvent was evaporated off on a rotary evaporator and the residue was chromatographed over silica gel (CH2Cl2 /methanol/triethylamine 9/1/0.1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05242908 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-3b1908a01a5143ef967011e4244289b7 |
| 出典メモ | uspto-grants-1993_09 |