1-Bromo-2-Chloroethane → 1-Chloro-2-[(2-chloroethyl)oxy]-4-nitrobenzene
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH2:14][Cl:15].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11][CH2:13][CH2:14][Cl:15]参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 2-chloro-5-nitrophenol (4 g, 23 mmol), 1-bromo-2-chloroethane (9 mL, 115 mmol), and K2CO3 (8 g, 58 mmol) in DMF (50 mL) was heated at 80° C. for 18 h. The mixture was diluted with water and extracted several times with EtOAc. The combined organic layers were washed with 1N NaOH (aq) and concentrated in vacuo to yield the title compound and a bromo adduct contaminant.
後処理
- extractionextracted several times with EtOAc
- washThe combined organic layers were washed with 1N NaOH (aq)
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-116b6bf81d2f4fffbc832b106ce0266e
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07531553B2
反応ノート
読み込み中…