Benzyl Isothiocyanate → 4-Benzyl-2-(4-methyl-benzyl)-[1,2,4]thiadiazolidine-3,5-dione

反応式

[CH2:1]([N:8]=[C:9]=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][C:12]1[CH:21]=[CH:20][C:15]([CH2:16][N:17]=[C:18]=[O:19])=[CH:14][CH:13]=1.C([O:24]CC)C>>[CH2:1]([N:8]1[C:9](=[O:24])[S:10][N:17]([CH2:16][C:15]2[CH:20]=[CH:21][C:12]([CH3:11])=[CH:13][CH:14]=2)[C:18]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

反応物 3

HCID 2346Benzyl Isothiocyanate

HCID 3283Diethyl Ether

HCID 27333881-(Isocyanatomethyl)-4-methylbenzene

生成物 1

HCID 115369104-Benzyl-2-(4-methyl-benzyl)-[1,2,4]thiadiazolidine-3,5-dione

実験手順

Reagents: Benzylisothiocyanate (6.5 mmol, 0.85 mL), 4-methylbenzyl-isocyanate (6.5 mmol, 0.90 mL) and SO2Cl2 (6.5 mmol, 0.52 mL) in diethyl ether (25 mL). Isolation: filtration of reaction mixture. Purification: recrystallization from MeOH.