2-Bromo-4-methoxy-6-nitrophenol → 2-Amino-6-Bromo-4-Methoxyphenol

HRID 491726ノート

反応式

HRID 491726 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([N+:10]([O-])=O)[C:3]=1[OH:13]>CCOC(C)=O.[Ni]>[NH2:10][C:4]1[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=[C:2]([Br:1])[C:3]=1[OH:13]

参加物

4

反応物 1

HCID 112651402-Bromo-4-methoxy-6-nitrophenol

生成物 1

HCID 111719822-Amino-6-Bromo-4-Methoxyphenol収率 96%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8857Ethyl Acetate溶媒

実験手順

Raney/Ni (2.5 g) was added into a solution of 2-bromo-4-methoxy-6-nitrophenol (8.8 g, 35.5 mmol) in EtOAc (100 mL). The mixture was shaken in a Parr apparatus under hydrogen at 25 psi for 2.5 h. The reaction mixture was filtered through celite and concentrated under vacuum to give a gray solid (7.4 g, 96% yield; 95-97° C.); MS m/e 218 (M+H)+.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated under vacuum
  3. customto give a gray solid (7.4 g, 96% yield; 95-97° C.)

出典と根拠

ORDレコード
ord-05ef32863ea14cbe9fbaea961923688d
出典データセット
uspto-grants-2009_05
特許番号
US07531564B2

反応ノート

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