7-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole → 7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol

反応式

Br[C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17]C)=[CH:13][CH:12]=3)=[N:7][C:6]=2[CH:5]=[C:4]([O:19]C)[CH:3]=1.Br[Zn][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:23]([C:2]1[C:10]2[O:9][C:8]([C:11]3[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=3)=[N:7][C:6]=2[CH:5]=[C:4]([OH:19])[CH:3]=1)[CH2:24][CH2:25][CH3:26]

参加物

反応物 2

HCID 121489697-Bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole

HCID 178448257HCID 178448257、化合物

生成物 1

HCID 1354997747-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol

実験手順

The title compound was prepared in substantially the same manner as described in Example 35, from 7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole, and bromo(butyl)zinc. The desired product was obtained as a white solid, m.p. 125-127° C.; MS m/e 282 (M−H)+.

後処理

customThe title compound was prepared in substantially the same manner

出典と根拠

ORDレコード: ord-915c5398e12d46278c12a3099f3eac7b
出典データセット: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07531564B2

反応ノート

読み込み中…

参加物