3-Oxabicyclo[3.3.1]nonane-2,4-dione → 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]-butyl)-3-azabicyclo[3.3.1]nonan-2,4-dione

HRID 4919

反応式

HRID 4919 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1.[CH:18]12[CH2:26][CH:22]([CH2:23][CH2:24][CH2:25]1)[C:21](=[O:27])[O:20][C:19]2=O>>[N:17]1[CH:16]=[CH:15][CH:14]=[N:13][C:12]=1[N:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]2[C:19](=[O:20])[CH:18]3[CH2:26][CH:22]([CH2:23][CH2:24][CH2:25]3)[C:21]2=[O:27])[CH2:11][CH2:10]1

参加物

3

反応物 2

HCID 4195063-Oxabicyclo[3.3.1]nonane-2,4-dioneHCID 128407054-(2-Pyrimidinyl)-1-piperazinebutanamine

生成物 1

HCID 140971673-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]-butyl)-3-azabicyclo[3.3.1]nonan-2,4-dione収率 47%

実験手順

Following substantially the procedure of Example 1, 2.78 g (11.8 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl) piperazine was reacted with 1.88 g (12.2 mmol) of 3-oxabicyclo[3.3.1]nonan-2,4-dione. The product was chromatographed on silica gel, eluting with dichloromethane/methanol (90:10), to give 2.04 g (47% yield) of the title compound.

後処理

  1. customThe product was chromatographed on silica gel
  2. washeluting with dichloromethane/methanol (90:10)

出典と根拠

ORDレコード
ord-443f179a2fda400bab688522515184dd
出典データセット
uspto-grants-1993_09
特許番号
US05242911

関連ノート

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