化工社化工社 化学情報印刷レポート · 研究参考用
Methylamine → N-methyl-3-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 3-Nitrobenzoic acid | HCID 8497 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | N-methyl-3-nitrobenzamide | HCID 221964 | — |
反応手順
Commercially available 3-nitrobenzoic acid is reacted with methylamine and EDC under standard conditions to afford N-methyl-3-nitrobenzamide, which is reduced with LAH under standard conditions to afford N-methyl(3-nitrophenyl)methanamine, which is protected with benzylchloroformate under standard conditions to yield t-butyl 3-nitrobenzylmethylcarbamate. This material is nitrosated and reduced to yield t-butyl 3-hydrzazinobenzylmethylcarbamate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07531566B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-60993d249c19478ba59a7dd508a38856 |
| 出典メモ | uspto-grants-2009_05 |