3-Nitrobenzamide → 3-Nitrobenzylamine

HRID 492034ノート

反応式

HRID 492034 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:9])=O)([O-:3])=[O:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:7][NH2:9])[CH:10]=[CH:11][CH:12]=1)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 125763-NitrobenzamideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 1227223-Nitrobenzylamine

実験手順

Commercially available 3-nitrobenzamide is reduced with LAH under standard conditions to afford (3-nitrophenyl)methanamine, which is reacted with succinic anhydride under standard conditions to afford 1-(3-nitrobenzyl)pyrrolidine-2,5-dione. This material is reduced at the nitro group and oxidized to afford 1-(3-hydrazinobenzyl)pyrrolidine-2,5-dione.

出典と根拠

ORDレコード
ord-6bdfe517728348d49aa48d175d29dc41
出典データセット
uspto-grants-2009_05
特許番号
US07531566B2

反応ノート

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