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Phenylurea → 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylurea | HCID 6145 | — |
| 反応物 | (Chlorothio)formyl chloride | HCID 75990 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Phenyl-1,2,4-thiadiazolidine-3,5-dione | HCID 18449884 | 20% |
反応手順
To the solution of phenyl-urea (13.0 g, 95.48 mol) in THF (100 mL) was slowly added chlorocarbonyl sulfenylchloride (13 mL, 148.85 mmol) at RT. The reaction mixture was refluxed overnight, the volatiles removed in vacuo yielded 2-phenyl-1,2,4-thiadiazolidine-3,5-dione as a white solid (4.0 g, 20%). 1H NMR (DMSO-d6): δ 12.49 (s, 1H), 7.51 (d, J=8.0 Hz, 2H), 7.43 (t, J=7.6 Hz, 2H), 7.27 (t, J=7.2 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07531566B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-759bce7b25b84c5180437af1d44f6f5c |
| 出典メモ | uspto-grants-2009_05 |