Ammonium Acetate → 1-Amino-5-(2,5-difluorophenyl)cyclohexan-3-one

HRID 49205ノート

反応式

HRID 49205 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH2:12]1

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 178239175-(2,5-Difluorophenyl)cyclohexane-1,3-dione

生成物 1

HCID 178239181-Amino-5-(2,5-difluorophenyl)cyclohexan-3-one収率 92.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5-(2,5-difluorophenyl)cyclohexane-1,3-dione (4.0 g) and ammonium acetate (4.1 g) in ethanol (60 ml) was heated under reflux for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was washed with water and dried to obtain 1-amino-5-(2,5-difluorophenyl)cyclohexan-3-one (3.7 g).

後処理

  1. temperatureunder reflux for 12 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washthe residue was washed with water
  4. customdried

出典と根拠

ORDレコード
ord-127ad5525e15414fa8391ce0006812bd
出典データセット
uspto-grants-2004_03
特許番号
US06706732B1

反応ノート

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