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1-Hydroxybenzotriazole → {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | N-Carbobenzoxysarcosine | HCID 97053 | — |
| 反応物 | 3-(Dimethylamino)propyl-ethyl-(iminomethylidene)azanium | HCID 21883392 | — |
| 反応物 | N-(5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide | HCID 57678964 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester | HCID 57678985 | — |
反応手順
A mixture of N-(5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide, (Benzyloxycarbonyl-methyl-amino)-acetic acid, 1-hydroxybenzotriazole, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and triethylamine in methylene chloride is stirred at room temperature. The reaction is quenched by addition of water, and the mixture is eluted through silica gel to give {[(6-Benzenesulfonylamino-naphthalen-1-ylmethyl)-carbamoyl]-methyl}-methyl-carbamic acid benzyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07531577B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-4366e0d83b2f484e97dba99d5a6ef4ff |
| 出典メモ | uspto-grants-2009_05 |