1,5-Dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dione → 3-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1, 5-dimethyl-3-azabicyclo[3.2.1]octan-2,4-dione

HRID 4921

反応式

HRID 4921 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1.[CH3:18][C:19]12[CH2:26][C:23]([CH3:27])([CH2:24][CH2:25]1)[C:22](=[O:28])[O:21][C:20]2=O>>[N:17]1[CH:16]=[CH:15][CH:14]=[N:13][C:12]=1[N:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]2[C:22](=[O:28])[C:23]3([CH3:27])[CH2:26][C:19]([CH3:18])([CH2:25][CH2:24]3)[C:20]2=[O:21])[CH2:11][CH2:10]1

参加物

3

反応物 2

HCID 125302711,5-Dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dioneHCID 128407054-(2-Pyrimidinyl)-1-piperazinebutanamine

生成物 1

HCID 140971663-(4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl)-1, 5-dimethyl-3-azabicyclo[3.2.1]octan-2,4-dione収率 21%

実験手順

Following substantially the procedure of Example 1, 4.2 g (17.8 mmol) of 1-(4-aminobutyl)-4-(2-pyrimidinyl) piperazine was reacted with 2.99 g (17.8 mmol) of 1,5-dimethyl-3-oxabicyclo[3.2.1]octan-2,4-dione. The product was chromatographed on silica gel, eluting with dichloromethane/methanol (96:4), to give 1.4 g (21% yield) of the title compound.

後処理

  1. customThe product was chromatographed on silica gel
  2. washeluting with dichloromethane/methanol (96:4)

出典と根拠

ORDレコード
ord-e56e486a103f4058a11eaf6d3e707e63
出典データセット
uspto-grants-1993_09
特許番号
US05242911

関連ノート

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