化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → N'-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N'-heptyl-N-(2,4,6-trifluorophenyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 反応物 | 2,4,6-Trifluorobenzoic acid | HCID 520373 | — |
| 反応物 | N-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N-heptylamine | HCID 68851407 | — |
| 生成物 | N'-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N'-heptyl-N-(2,4,6-trifluorophenyl)urea | HCID 68851965 | 81% |
反応手順
Using 2,4,6-trifluorobenzoic acid (0.27 g), diphenylphosphoryl azide (0.44 g), triethylamine (0.17 g) and N-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N-heptylamine (0.43 g), N′-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N′-heptyl-N-(2,4,6-trifluorophenyl)urea was afforded as colorless crystals (0.49 g) by a similar procedure as in Example 4. Yield: 81%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07531576B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-93713c4e2de840a385d60127aa87377e |
| 出典メモ | uspto-grants-2009_05 |