化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 2-{[2-(Allyloxy)-4-(benzyloxy)phenoxy]methyl}oxirane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Glycidyl tosylate, (R)- | HCID 154187 | — |
| 反応物 | 2-Allyloxy-4-(benzyloxy)phenol | HCID 18546012 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-{[2-(Allyloxy)-4-(benzyloxy)phenoxy]methyl}oxirane | HCID 18546022 | — |
反応手順
Sodium hydride (4.3 g, 0.11 mole of 60% mineral oil dispersion) was washed with hexane and suspended in 100 mL of N,N-dimethylformamide. To this suspension was added a solution of 25.4 g (0.10 mole) of 2-allyloxy-4-(benzyloxy)phenol in 100 mL of DMF. The mixture was stirred at room temperature for 30 minutes and then 22.8 g (0.10 mole) of (2R)-(−)-glycidyl tosylate was added.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706736B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-6233de2de6f143688edd4dcfaa46e9b9 |
| 出典メモ | uspto-grants-2004_03 |