(1S)-(+)-Camphor-10-sulphonic acid → 4-(1-Methylazetidin-3-yl)piperazine-1-carboxylic acid [6-(2-fluoro-4-{3-[2-(4-fluorophenyl)acetyl]thioureido}phenoxy)pyrimidin-4-yl]amide

反応式

[C@]12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O.[NH2:16][C:17]1[CH:43]=[CH:42][C:20]([O:21][C:22]2[N:27]=[CH:26][N:25]=[C:24]([NH:28][C:29]([N:31]3[CH2:36][CH2:35][N:34]([CH:37]4[CH2:40][N:39]([CH3:41])[CH2:38]4)[CH2:33][CH2:32]3)=[O:30])[CH:23]=2)=[C:19]([F:44])[CH:18]=1.[F:45][C:46]1[CH:51]=[CH:50][C:49]([CH2:52][C:53]([N:55]=[C:56]=[S:57])=[O:54])=[CH:48][CH:47]=1>C(O)C.C1(C)C=CC=CC=1>[F:44][C:19]1[CH:18]=[C:17]([NH:16][C:56]([NH:55][C:53](=[O:54])[CH2:52][C:49]2[CH:50]=[CH:51][C:46]([F:45])=[CH:47][CH:48]=2)=[S:57])[CH:43]=[CH:42][C:20]=1[O:21][C:22]1[N:27]=[CH:26][N:25]=[C:24]([NH:28][C:29]([N:31]2[CH2:32][CH2:33][N:34]([CH:37]3[CH2:40][N:39]([CH3:41])[CH2:38]3)[CH2:35][CH2:36]2)=[O:30])[CH:23]=1