4-(Dimethylamino)Benzaldehyde → (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-(dimethylamino)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

HRID 493010

反応式

HRID 493010 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([CH3:16])=[N:11]1.[CH3:17][N:18]([CH3:27])[C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=1.N1CCCCC1>C(O)C.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[N:10]1[C:14](=[O:15])/[C:13](=[CH:23]/[C:22]2[CH:25]=[CH:26][C:19]([N:18]([CH3:27])[CH3:17])=[CH:20][CH:21]=2)/[C:12]([CH3:16])=[N:11]1

参加物

6

反応物 3

HCID 74794-(Dimethylamino)BenzaldehydeHCID 8082PiperidineHCID 459449Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl-

生成物 1

HCID 57679781(4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-(dimethylamino)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

1 g (4.32 mmol) of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and 1.93 g (12.96 mmol) of 4-(dimethylamino)benzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the bright red precipitate is filtered off, then washed with water and a small amount of cold methanol and dried under reduced pressure.

後処理

  1. filtrationthe bright red precipitate is filtered off
  2. washwashed with water
  3. dry with materiala small amount of cold methanol and dried under reduced pressure

出典と根拠

ORDレコード
ord-97853ff632404409a3f0993a6fe48090
出典データセット
uspto-grants-2009_05
特許番号
US07534273B2

関連ノート

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