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Vanillin → (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Vanillin | HCID 1183 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Pyrazol-5(4H)-one, 1-(2-benzothiazolyl)-3-methyl- | HCID 459449 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (4E)-2-(1,3-benzothiazol-2-yl)-4-{[4-hydroxy-3-(methyloxy)phenyl]-methylidene}-5-methyl-2,4-dihydro-3H-pyrazol-3-one | HCID 136385044 | — |
反応手順
1 g (4.32 mmol) of 2-(1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one and 1.97 g (12.96 mmol) of 4-hydroxy-3-methoxybenzaldehyde are stirred under reflux with the addition of 3 ml of piperidine in absolute ethanol for 2 hours. The mixture is then diluted with water and the orange-yellow precipitate is filtered off, then washed with water and a small amount of cold methanol and dried under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07534273B2 |
| 出典データセット | uspto-grants-2009_05 |
| ORD ID | ord-05cff674b3534b0793ca50617ff8a74e |
| 出典メモ | uspto-grants-2009_05 |