Potassium Hydroxide → 1-Ethynyl-4-propylbenzene

HRID 493031

反応式

HRID 493031 の反応式
[OH-].[K+].[CH2:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][CH:7]=1)[CH2:4][CH3:5]>CO>[CH2:3]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[CH:13])=[CH:10][CH:11]=1)[CH2:4][CH3:5]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 193534011-(4-n-Propylphenyl)-2-trimethylsilylacetylene

生成物 1

HCID 27751331-Ethynyl-4-propylbenzene収率 99.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Methanol (150 ml) and an aqueous solution of 1N-potassium hydroxide (100 ml) were added to 14.2 g (65.7 mmol) of 1-(4-n-propylphenyl)-2-trimethylsilylacetylene synthesized in the step (i), and the mixture was subjected to hydrolysis with vigorously stirring overnight. After completion of the reaction, methanol was removed and the resultant residue was extracted with hexane. After removing hexane from the hexane phase, the resultant residue was washed with water to give 9.4 g (65.3 mmol) of 4-n-propylphenylacetylene.

後処理

  1. customsynthesized in the step (i)
  2. customthe mixture was subjected to hydrolysis
  3. customwas removed
  4. extractionthe resultant residue was extracted with hexane
  5. customAfter removing hexane from the hexane phase
  6. washthe resultant residue was washed with water

出典と根拠

ORDレコード
ord-b6c976575fa84c26b28100f46a3d5f38
出典データセット
uspto-grants-2009_05
特許番号
US07534547B2

関連ノート

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