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Hydrochloric Acid → 1-[4-(Tert-butoxycarbonyl)phenyl]-2-(4-n-propyloxyphenyl)acetylene

HRID 493042
ノート
印刷プレビュー

反応式

HRID 493042 の反応式
C([C:5]1([CH:13]=[CH:12][C:11](Br)=[CH:10][CH2:9]1)[C:6]([O-:8])=[O:7])(C)(C)C.[CH2:15]([O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[CH:26])=[CH:21][CH:20]=1)[CH2:16][CH3:17].[CH2:27]([C:30]1[CH:35]=CC(Br)=C[CH:31]=1)CC.C[Si](C#C)(C)C.Cl>O>[C:30]([O:8][C:6]([C:5]1[CH:9]=[CH:10][C:11]([C:26]#[C:25][C:22]2[CH:21]=[CH:20][C:19]([O:18][CH2:15][CH2:16][CH3:17])=[CH:24][CH:23]=2)=[CH:12][CH:13]=1)=[O:7])([CH3:35])([CH3:31])[CH3:27]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 66111TrimethylsilylacetyleneHCID 1363741-Bromo-4-propylbenzeneHCID 27751231-Ethynyl-4-propoxybenzeneHCID 229258901-Tert-butyl-4-bromobenzoate

生成物 1

HCID 229258451-[4-(Tert-butoxycarbonyl)phenyl]-2-(4-n-propyloxyphenyl)acetylene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The reaction was conducted in the same manner as in the step (i) of the Example 31, except for using 1-tert-butyl-4-bromobenzoate synthesized in the step (i) and 4-n-propyloxyphenylacetylene synthesized in the step (iii) of the Example 32 instead of 1-n-propyl-4-bromobenzene and trimethylsilylacetylene, respectively. After completion of the reaction, the reaction mixture was poured into an iced water, and the resultant mixture was acidified by adding hydrochloric acid. The resultant solid was collected by filtration, washed with water, dried, and recrystallized from hexane to give 1-[4-(tert-butoxycarbonyl)phenyl]-2-(4-n-propyloxyphenyl)acetylene.

後処理

  1. customAfter completion of the reaction
  2. filtrationThe resultant solid was collected by filtration
  3. washwashed with water
  4. customdried
  5. customrecrystallized from hexane

出典と根拠

ORDレコード
ord-41726123643a468e84f1e45cb2379082
出典データセット
uspto-grants-2009_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07534547B2

反応ノート

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