Ethyl Acetate → ethyl 4,7-difluoro-1H-indole-2-carboxylate
反応式
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:12]=[O:13])[NH:6]2.[C:14](OCC)(=[O:16])[CH3:15]>>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12]([O:16][CH2:14][CH3:15])=[O:13])[NH:6]2参加物
3
実験手順
The cooled mixture was dissolved in ethyl acetate, washed with sodium bicarbonate and brine, dried and evaporated. Chromatography on silica gel (1:1 dichloromethane/petrol) followed by recrystallization (dichloromethane/hexane) gave the indole ester (0.75 g). (f) 4,7-Difluoroindole-2-carboxaldehyde
後処理
- washwashed with sodium bicarbonate and brine
- customdried
- customevaporated
- customChromatography on silica gel (1:1 dichloromethane/petrol) followed by recrystallization (dichloromethane/hexane)
- customgave the indole ester (0.75 g)
出典と根拠
- ORDレコード
- ord-dd3df5976fb640cbaad59042b33b9d69
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07534793B2
反応ノート
読み込み中…