反応式
[C:1]([Si:5]([CH3:8])([CH3:7])Cl)([CH3:4])([CH3:3])[CH3:2].[CH2:9]([OH:13])[C@H:10]([OH:12])[CH3:11].N1C=CN=C1>ClCCl>[O:13]([CH2:9][C@H:10]([OH:12])[CH3:11])[Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:8])[CH3:7]参加物
5
実験手順
A solution of tert-butyldimethylchlorosilane (9.9 g, 65.7 mmol) in dichloromethane was added dropwise to a solution of (R)-(−)-1,2-propanediol (5 g, 65.7 mmol) and imidazole (4.47 g, 65.7 mmol) in anhydrous dichloromethane at 0° C. The reaction mixture was stirred at 0° C. for 30 min before dilution with dichloromethane. The solution was washed with water three times followed by the addition of brine. The organic layer was separated, dried through a MgSO4 pad and concentrated under reduced pressure to afford 12.0 g (96%) of (2R)-1-(tert-Butyldimethylsiloxy)propan-2-ol.
後処理
- washThe solution was washed with water three times
- additionfollowed by the addition of brine
- customThe organic layer was separated
- dry with materialdried through a MgSO4 pad
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-7aeeb593719a4b0ea9601e19858f3838
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07534813B2
関連ノート
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