Bromine → HCID 11565801、化合物
反応式
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Br:18]Br>C(O)C>[Br:18][CH2:14][C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:16]=[CH:17][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:8][CH:9]=1)=[O:15]参加物
4
実験手順
A solution of 1-[4-(4-fluorophenoxy)phenyl]ethanone (17.7 g, 0.077 mol) in 220 ml of ethanol is cooled down to approximately 0° C. Bromine (4.8 ml, 0.096 mol) is added dropwise with a syringe. The temperature is allowed to return to ambient temperature, followed by stirring for 2 hours. After evaporation of the solvent then stirring for 10 hours in isopentane, the residue is filtered on frit and dried under a vacuum chamber bell jar. A beige-coloured powder is obtained.
後処理
- customto return to ambient temperature
- customAfter evaporation of the solvent
- stirringthen stirring for 10 hours in isopentane
- filtrationthe residue is filtered on frit
- customdried under a vacuum chamber bell jar
- customA beige-coloured powder is obtained
出典と根拠
- ORDレコード
- ord-1005f21daa09443ab75616966a8c7631
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07534805B2
反応ノート
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