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4-Bromothiophene-2-carbaldehyde → 1-(4-Bromo-2-thienyl)-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(4-Bromo-2-thienyl)-1-propanol | HCID 22606901 | — |
反応手順
30 g (157 mmol) of 4-bromo-2-thiophenecarboxaldehyde are dissolved in 200 mL of anhydrous THF. 104 mL (312 mmol) of 3.0 M ethylmagnesium bromide are added slowly and the medium is stirred for 2 hours at room temperature. After the usual treatment, an orange-coloured oil is obtained (m=33.5 g; Y=96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706725B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-b2bca1c410a54470a65e171b381e8a24 |
| 出典メモ | uspto-grants-2004_03 |