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1-(4-Bromo-2-thienyl)-1-propanol → 4-Bromo-2-propionylthiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Bromo-2-thienyl)-1-propanol | HCID 22606901 | — |
| 触媒 | HCID 178418406 | HCID 178418406 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Bromo-2-propionylthiophene | HCID 818932 | — |
反応手順
33.5 g (151 mmol) of 1-(4-bromo-2-thienyl)-1-propanol are dissolved in 400 mL of dichloromethane. 130 g (1.5 mol) of manganese dioxide are then added portionwise and the medium is stirred at room temperature for 24 hours. After filtration through Celite and then concentration and chromatography on silica gel (eluent: 9 heptane/1 ethyl acetate), the desired product is obtained in the form of white crystals (m=26.6 g; Y=80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06706725B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-5d27fd9b2e004ef1b5d56e425461e493 |
| 出典メモ | uspto-grants-2004_03 |